Figure 1.

Shc isoform expression is developmentally regulated. Western analysis (A) and densitometry (B) were performed on normal baboon lungs at 125, 140, 160, and 175 days' gestation (term = 185 days), and postpartum (newborn, NB). p66^Shc content decreased with maturation (p = 0.011). Relative to Day 125, mean p66^Shc content decreased 74% by Day 140, 71% by Day 160, and 80% by Day 175 (*p = 0.05). Error bars represent SD throughout this report. Expression of p46^Shc fell 67% over the same period. p66^Shc expression increased 2.02-fold (p = 0.034) after Day 175. Changes in p52^Shc content were not statistically significant.