TABLE 5.
Inflammatory marker concentrations in lavage samples after single-day and multiday ozone exposures
| Samples (n = 13) | Normal Values* | 1-D | MD4 | p Value |
|---|---|---|---|---|
| BFx | ||||
| IL-6, pg/ml | 5.2 ± 4.9 | 6.0 ± 3.7 | 5.5 ± 6.7 | 0.740 |
| IL-8, pg/ml | 24.3 ± 21.4 | 49.1 ± 28.6 | 61.8 ± 58.1 | 0.752 |
| MPO, ng/ml | N/A | 42.9 ± 31.9 | 43.2 ± 24.0 | 0.970 |
| BAL | ||||
| IL-6, pg/ml | 3.8 ± 3.1 | 4.5 ± 4.1 | 3.1 ± 2.0 | 0.083 |
| IL-8, pg/ml | 20.7 ± 32.4 | 23.1 ± 19.1 | 26.9 ± 39.7 | 0.895 |
| MPO, ng/ml | 4.2 ± 1.8 | 18.0 ± 13.5 | 17.3 ± 25.5 | 0.898 |
Definition of abbreviations: 1-D = single-day O3 exposure; BAL = bronchoalveolar lavage; BFx = bronchial fraction; IL = interleukin; MD4 = multiday O3 exposure; MPO = myeloperoxidase; N/A = not available.
The concentration of IL-6, IL-8, and MPO in BFx (the first 15-ml return of the lavage sample) and BAL (the remainder of the lavage return) after instillation of a total of 100 ml of normal saline into the right middle lobe. Values shown are mean ± SD. p values are for paired Student's t test between 1-D and MD4 measurements.
*
Values obtained in previous studies of filtered-air–exposed, nonsmoking subjects with asthma in our laboratory (28, 46).