Figure 1.

Top: Schematic representation of the TNF genes on chromosome 6 in relation to other important innate immunity genes in the area. TNF includes lymphotoxin-α (LTA), tumor necrosis factor-α (TNF), and lymphotoxin-β (LTB). COMP = complement; HSP = heat shock 70-kD protein-1 and 90-kD protein-1; MHC = major histocompatibility complex (human leukocyte antigens DP, DQ, DR); SNP = single-nucleotide polymorphism. Bottom: TNF and LTA with SNP locations; the solid boxes denote exons and the open boxes denote the 5′ and 3′ untranslated regions. Not drawn to scale. (The top portion of this diagram was modified from Reference 39.)