TABLE 1.
Studies evaluating the association of tnf 308 and lta ncoi polymorphisms for asthma
| TNF –308*,‡
|
LTA NcoI‡
|
||||||
|---|---|---|---|---|---|---|---|
| First Author, Year | Reference | Population | Design | G | A | G | A |
| Moffatt, 1997 | 5 | White, 413 subjects from 88 families: 318 nonasthmatic and 92 with asthma (32 asthmatic parents and 60 children) |
Case-control | – | + | + | – |
| Albuquerque, 1998* | 19 | White, 74 children with atopic asthma and 50 unrelated control subjects | Case-control | + | – | – | + |
| Moffatt, 1999† | 16 | White, 1,004 subjects in 230 nuclear families; 179 were asthmatic (66 parents and 113 children) | Case-control | NS | NS | NS | NS |
| Li Kam Wa, 1999* | 4 | Mixed race, 556 subjects tested for bronchial hyperreactivity (246 hyperreactive); also sample of 60 extended families of an asthmatic proband | Case-control | – | + | NS | NS |
| Chagani, 1999 | 3 | White, 92 with mild–moderate asthma, 159 with fatal/near-fatal asthma, 43 nonasthmatic, 252 random control subjects |
Case-control | – | + | ||
| Trabetti, 1999 | 17 | White, 600 families with 131 children with atopic asthma | Sibling-pairs | NS | NS | NS | NS |
| Winchester, 2000 | 8 | White, 20 subjects with asthma identified by questionnaire for history of childhood asthma and 416 control subjects | Case-control | – | + | ||
| Louis, 2000 | 15 | White adults, 95 subjects with asthma and 98 control subjects | Case-control | NS | NS | ||
| Zhu, 2000 | 18 | White children, 12 with asthma and 269 nonasthmatic | Family based | NS | NS | ||
| Cardaba, 2001 | 23 | Spanish gypsies, 5 families with 87 people | Case-control | NS | NS | ||
| Izakovicova, 2001 | 25 | Czech, 243 white with atopy (167 had asthma) and 184 control subjects | Case-control | NS | NS | ||
| Immervol, 2001 | 24 | White, 97 families with 2 or more siblings with asthma | Family based | NS | NS | ||
| Lin, 2002 | 14 | Taiwanese, 80 subjects with high-IgE asthma and 69 nonasthmatics | Case-control | NS | NS | NS | NS |
| Noguchi, 2002 | 26 | Japanese, 144 atopic asthma families; transmission disequilibrium tests done | Family based | NS | NS | ||
| Witte, 2002 | 9 | White, 169 asthma cases and 170 control subjects | Case-control | – | + | NS | NS |
| Buckova, 2002 | 11 | Czech, 151 patients with atopic asthma and 155 control subjects | Case-control | NS | NS | NS | NS |
| Di Somma, 2003 | 12 | Italian, 70 patients with asthma and 169 without asthma from 51 nuclear families | Case-control | NS | NS | ||
| El Bahlawan, 2003 | 13 | Mixed race, children: 38 with asthma and 231 control subjects | Case-control | NS | NS | NS | NS |
| Sandford, 2004 | 6 | Chinese, 107 children with wheeze in the last 12 mo and 118 without wheeze | Case-control | – | + | ||
| Shin, 2004 | 20 | Korean, 550 with asthma and 171 control subjects | Case-control | + | – | NS | NS |
| Beghe, 2004 | 10 | 142 toluene diisocyanate–induced asthma cases and 50 asymptomatic exposed control subjects | Case-control | NS | NS | ||
| Wang, 2004 | 7 | Taiwanese children, 128 with atopic asthma, 51 with nonatopic asthma, 55 atopic control subjects, and 78 nonatopic control subjects | Case-control | – | + | NS | NS |
Definition of abbreviations: LTA = lymphotoxin-α; NS = not significant; TNF = tumor necrosis factor.
*
Positive association found in individuals homozygous for the allele.
†
The Moffatt and coworkers (1999) study (16) includes the same population as the Moffatt and Cookson (1997) population (5).
‡
A significant (p ≤ 0.05) association, with the + allele increased and the – allele decreased in the subjects with asthma; NS, no significant differences found.