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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Clin Cancer Res. 2009 Feb 15;15(4):1411–1416. doi: 10.1158/1078-0432.CCR-08-1141

Table 1.

Dose levels for combination sorafenib+bevacizumab trial

Dose Level Number of
Patients		 Sorafenib Bevacizumab
1 30 200 mg BID 5 mg/kg q2wk
2 6 200 mg BID 10 mg/kg q2wk
3 Not accrued 400 BID 10 mg/kg q2wk
4 4 200 mg BID
5 days each week		 5 mg/kg q2wk
5A 1 200 mg BID
5 days each week		 10 mg/kg q2wk
5B 1 400 BID
5 days each week		 5 mg/kg q2wk