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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Clin Cancer Res. 2009 Feb 15;15(4):1411–1416. doi: 10.1158/1078-0432.CCR-08-1141

Table 2.

Hand-foot skin reaction grading

Grading for hand-foot skin reaction*
Grade 1 Minimal skin changes or dermatitis (e.g erythema) without pain
Grade 2 Skin changes (e.g peeling, blisters, bleeding, edema) or pain not interfering with function
Grade 3 Ulcerative dermatitis or skin changes with pain interfering with function
Grade 4 None
*

Based on NCI Common Terminology Criteria for Adverse Events version 3.0