Fig. 2.

Pimecrolimus dose effect on endpoint eosinophil superoxide production. Mean superoxide anion (sO₂⁻) production after incubating for 180 min in the absence (0 nM) and presence of increasing concentrations of pimecrolimus (1 to 1,000 nM) are shown. Values are from figure 1 following stimulation of normal or atopic donor eosinophils with PAF, IL5 or immobilized sIgA. Significant changes in superoxide anion production relative to stimuli alone (i.e. 0 nM pimecrolimus) are indicated by asterisks. ∗ p < 0.05; ∗∗ p < 0.01. Standard errors of the means are indicated by unidirectional error bars.