. Author manuscript; available in PMC: 2009 Jul 30.

Published in final edited form as: Magn Reson Med. 2009 May;61(5):1059–1065. doi: 10.1002/mrm.21939

Table 1.

In vitro characteristics of liposomes collected using Sepharose® CL-2B gel column

	Diameter (nm) ^1, ^2		Polydispersity Index ± S.D.	ζ-potential (mV) ± ζ deviation ^*1	Gd or FU amount (µmol) ± S.D. ^*3
	Mode ± S.D.	Mean ± width	Polydispersity Index ± S.D.	ζ-potential (mV) ± ζ deviation ^*1	Gd or FU amount (µmol) ± S.D. ^*3
Lip	118 ± 21	127 ± 28	0.09 ± 0.08	−11 ± 7	—
Lip-Gd	117 ± 9	125 ± 26	0.03 ± 0.02	−9 ± 8	0.34 ± 0.02
Lip-FU	111 ± 9	123 ± 27	0.03 ± 0.02	−11 ± 8	1.30 ± 0.09
Lip-Fe	129 ± 6	139 ± 27	0.04 ± 0.03	−11 ± 8	—
Lip-Gd/Fe	125 ± 6	138 ± 33	0.11 ± 0.06	−11 ± 7	0.38 ± 0.10
Lip-FU/Fe	129 ± 12	141 ± 32	0.04 ± 0.02	−12 ± 8	1.73 ± 0.31

^*1

Liposomes were dispersed in PBS (pH 7.4) for the size measurement, and dispersed in 10 mM of NaCl for the ζ-potential measurement.

^*2

The hydrodynamic diameter of liposomes was calculated by the Stokes-Einstein equation.

^*3

Amount of GdDTPA-BMA or 5-FU in 1 mL liposome fraction collected using Sepharose® CL-2B gel column.