Table IV.

The CDR3 sequence of nonproductive compound rearrangements

Source	Accession Number	Functionality		CDR3 DNA Sequence
			codon 104	VH	N	D	N	JH
ND	EF542652	Stop codon in D segment	TGT	GCG AGA--	CAT GGA CGC CAC G	-------GG TGG TAA----	TTC TG	----C TTT GAC TAC
ND	EF542614	Stop codon in D segment	TGT	GCG AGA --	CTT ACT C	----TA TTGTAGGAG TAT CAG CTG-------	GTA AGT C	---AC TGG TTC GAC CCC
X-HIgM	EF541613	Stop codon in D segment	TGT	GCG AGA--	CGG GGT ACT	AGG ATA TTGTAG TAGTAC CAG CTG C-	GC	---A TAC GCT GCT TTT GAT ATC
X-HIgM	EF541884	Stop codon in DJH junction	TGT	GCG AGA--	CAA AGA GGG TGG AC	-T ACC AGC TGC T---------	TA TGA TGA GTG GGG	--TAC TAC TAC TAC TAC GGT ATG GAC GTC
X-HIgM	EF542038	Stop codon in DJH junction and JH is out of frame	TGT	GCG AGA--	CCC	GTA TTA CGA TTT TTG GAG TGG TTA-------	GTC TATTG	---A CTA CTA CTA CTA CGG TAT GGA CGT C
X-HIgM	EF542108	JH is out of frame	TGT	GCG AC---	C CTG	GGG TAT AGC AGT GGC TGG---	CC	----------------CTC
AICDA−/−	EU238603	Stop codon in VD junction and JH is out of frame	TGT	--------	GAC AC	G TAT TAC TAT GGT TCG GGG AGT CAT TAT---	TCC ATT CG	A CTA CTA CTA CTA CAT GGA CGT C

All of the nonproductive compound rearrangements from each database are displayed. The reading frame for each CDR3 is derived from the primary IGHV4bDJH rearrangements. Stop codons are in bold face type, dashes (---) represent nucleotides excised from germline genes during recombination and N= nontemplated nucleotides inserted by terminal deoxynucleotidyl transferase (TdT).