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. 2009 Aug 14;5(8):e1000602. doi: 10.1371/journal.pgen.1000602

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Christensen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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For (A–F), the top plot is the estimate of mean regression coefficients for age associated methylation (by decade), and its 95% confidence interval from GEE for each CpG RPMM class. The middle plot is of CpGs clustered with RPMM into eight classes for each group of samples. The bottom plot indicates the CpG island status for each locus (where magenta = CpG island locus, green = non-CpG island locus). (A) Estimates of class-specific age-associated methylation among all solid tissues (n = 119), RPMM clustering of CpGs, and CpG island status. Age-associated methylation is significantly increased among classes with a high prevalence of CpG-island loci (P = 2.3E-08). (B) Estimates of class-specific age-associated methylation among blood samples (n = 29), RPMM clustering of CpGs, and CpG island status. Age-associated methylation is significantly decreased among classes with a high prevalence of non-CpG-island loci (P = 6.3E-06). (C) Estimates of class-specific age associated methylation among pleural tissues (n = 18), RPMM clustering of CpGs, and CpG island status. Age-associated methylation is significantly increased among classes with a high prevalence of CpG-island loci (P = 2.3E-08). (D) Estimates of class-specific age-associated methylation among lung tissues (n = 52), RPMM clustering of CpGs, and CpG island status. (E) Estimates of class-specific age-associated methylation among brain tissues (n = 11), RPMM clustering of CpGs, and CpG island status. Age-associated methylation is significantly increased for the predominantly CpG island loci in class 3, and significantly decreased among classes with a high prevalence of non-CpG-island loci (P = 7.0E-04). (F) Estimates of class-specific age associated methylation among head and neck tissues (n = 10), RPMM clustering of CpGs, and CpG island status. Age-associated methylation is significantly decreased among classes with a high prevalence of non-CpG-island loci (P = 5.2E-08).