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. 2009 Aug 25;7(8):e1000177. doi: 10.1371/journal.pbio.1000177

Figure 6. A cyclooxygenase (COX)-derived eicosanoid is required for neutrophil transmigration across TNF-stimulated endothelial cells.

Figure 6

(A) Inhibition of COX-1 (SC-560), COX-2 (NS-398), or both (indomethacin) caused inhibition of neutrophil transmigration, *p<0.05 by t-test. (B) Addition of AA to EPA-supplemented endothelial cells during the period of TNF stimulation restored neutrophil transmigration. All data are mean±SEM of four experiments. ANOVA showed significant effects of treatments in both (A and B) (p<0.01). In (A), Dunnett test showed significant effects of individual treatments compared to untreated control, *p<0.05. In (B), Dunnett's test showed significant difference between EPA-treated and untreated control (**p<0.01), but not between AA+EPA and control.