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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Bioorg Med Chem. 2008 Oct 14;16(23):10022–10028. doi: 10.1016/j.bmc.2008.10.024

Figure 2.

Figure 2

Diplamine B (4) and lissoclinidine B (5) increased p53 and Hdm2 in cells in a dose-dependent manner. RPE cells were treated with 50 µM ALLN, or 1–10 µM 4 or 5 for 8 h. Total levels of p53, Hdm2 and β-actin, which serves as an equal loading control, were assessed by immunoblotting using antibodies directed against each of these proteins.