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PGC-1α and PGC-1α 2x9 induce gene expression of CYP11A1 and CYP17A1 in hepatic cells. Gene expression of CYP11A1 and CYP17A1 was measured by quantitative PCR in HepG2 cells (A), Hep3B cells (B), or primary human hepatocytes (C) infected with adenoviruses expressing β-gal, PGC-1α, PGC-1α 2x9, or PGC-1α L2L3M. Gene expression was normalized to 36B4 expression. Error bars represent sem of three replicates, and each graph is representative of at least three independent experiments.
