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. 2008 Dec 31;85(4):648–655. doi: 10.1189/jlb.0708428

Fig. 4.

Fig. 4.

B cells from PD patients constitutively up- and down-regulate genes in TLR pathways. (A) Superarray plate analysis comparing unstimulated B cells from three PD patients and three healthy donors (for a total of nine comparisons). Shown are genes up-regulated (black bars), unchanged (gray bars), or down-regulated (white bar) in B cells isolated from PD peripheral blood, purified and then rested for 1 h on ice prior to analysis. (B) Gene expression in B cells from PD patients versus healthy donors incubated ex vivo in media alone for 24 h. Shown is the average and sd of values obtained from two donor samples from each cohort (for a total of four comparisons). *, Statistical significance (P<0.05) by the Student’s t-test. Additional genes that approached significant differences (P<0.08) were IRF-1 and cJun (A) and MyD88 and NF-κB-1 (B). IKK-beta, IκB kinase; AGMX1, Bruton’s tyrosine kinase.