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. 2009 Apr 1;85(6):928–938. doi: 10.1189/jlb.1008621

Fig. 7.

Fig. 7.

Regulation of Wnt and adipogenic genes during aging and by CR. (A) Western blot analysis of β-catenin and Wnt10b in the thymus did not show any significant changes. (B) Thymic mRNA expression of Wnt antagonist Nkd1 in mice is not affected by age (n=6). (C) The real-time PCR analysis of adipogenic transcripts in the thymus shows that aging leads to a significant (P<0.05) reduction in Pref-1 without affecting CHOP and KLF6 mRNA expression. Compared with 3-month-old mice, no differences in IL-7 mRNA were observed in 12-month AL- and CR-fed mice.