Table 2.
Univariate comparisons for the study variables for progression-free survival in patients >3 years old at diagnosis and patients treated with high-dose chemotherapy and stem cell rescue (HDCSCR)
| Patients >3 Years Old at Diagnosis (n = 36)
|
Patients Treated with HDCSCR (n = 24)
|
|||||
|---|---|---|---|---|---|---|
| Variable | n (Event) | 4-Year PFS (SE) | HR (95% CI) | n (Event) | 4-Year PFS (SE) | HR (95% CI) |
| Age at diagnosis | ||||||
| <8 years | 17 (5) | 71 (11) | 1.5 (0.4–5.6) | 11 (5) | 55 (15) | 2.4 (0.6–10) |
| >8 years | 19 (4) | 76 (11) | 1 | 13 (3) | 71 (14) | 1 |
| Gender | ||||||
| Male | 28 (6) | 78 (8) | 1 | 19 (6) | 68 (11) | 1 |
| Female | 8 (3) | 50 (22) | 2.3 (0.6–9.3) | 5 (2) | 40 (30) | 1.6 (0.3–8) |
| Risk group | ||||||
| High risk | 14 (5) | 64 (13) | 2.5 (0.7–9.3) | 9 (4) | 56 (17) | 2.2 (0.6–8.9) |
| Average risk | 22 (4) | 80 (9) | 1 | 15 (4) | 70 (13) | 1 |
| GSTM1 | ||||||
| Null | 13 (5) | 61 (14) | 2.3 (0.6–8.5) | 9 (5) | 44 (17) | 3 (0.7–13) |
| Nonnull | 23 (4) | 82 (8) | 1 | 15 (3) | 79 (11) | 1 |
| GSTT1 | ||||||
| Null | 11 (2) | 81 (12) | 1 | 5 (1) | 75 (22) | 1 |
| Nonnull | 25 (7) | 70 (10) | 1.6 (0.3–7.6) | 19 (7) | 62 (12) | 1.8 (0.2–15) |
| GSTM1T1 combined | ||||||
| ≥1 null | 20 (6) | 68 (11) | 1.7 (0.4–6.8) | 12 (5) | 55 (15) | 1.8 (0.4–7.7) |
| Nonnull | 16 (3) | 81 (10) | 1 | 12 (3) | 75 (13) | 1 |
Abbreviations: PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; GSTM1, glutathione S-transferase M1 polymorphism; GSTT1, glutathione S-transferase T1 polymorphism. “Event” refers to relapse or progression.