Table 6.

Multivariate Cox regression analysis of prognostic indicators for leptomeningeal melanomatosis

Factor	Contrast	Hazard Ratio (95% CI)	p-Value
Sex, n = 110	Male vs. female	1.1 (0.7–1.7)	0.67
Age, n = 110	≥ 50 years vs. < 50 years	1.1 (0.7–1.7)	0.83
Race, n = 110	White vs. other	1.4 (0.6–3.0)	0.42
Period of diagnosis, n = 110	1990 or after vs. before 1990	1.2 (0.6–2.3)	0.55
Site of cutaneous primary, n = 85	Head and neck vs. other	1.6 (0.8–3.2)	0.21
	Trunk vs. other	2.0 (1.0–3.8)	0.04
	Extremities vs. other	0.9 (0.5–1.6)	0.67
Proximity of melanoma to CNS, n = 108	Yes vs. no	1.5 (0.8–2.8)	0.21
Elevated ICP, n = 106	Yes vs. no	1.4 (0.9–2.1)	0.20
No. of parenchymal metastases, n = 106	Single vs. none	0.6 (0.3–1.2)	0.14
	Multiple vs. none	0.9 (0.5–1.6)	0.69
Signs and symptoms (s/s), n = 109	Cranial s/s present vs. absent	0.9 (0.4–1.7)	0.67
	Spinal s/s present vs. absent	1.1 (0.6–2.0)	0.84

Abbreviations: CI, confidence interval; ICP, intracranial pressure.