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Effects of nalfurafine intervention on intrathecal morphine-induced itch/scratching and antinociception against 50°C water. Nalfurafine (micrograms per kilogram intramuscularly) was given 45 min after intrathecal administration of 0.03 mg of morphine. Each value represents mean ± S.E.M. (n = 6). Symbols represent different dosing conditions for the same monkeys. *, significant difference from the vehicle condition between time points 1 and 2.5 h (p < 0.05).
