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. 2009 Aug 14;5(8):e1000600. doi: 10.1371/journal.pgen.1000600

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Daughters et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) qRT-PCR shows increased GABT4 RNA in frontal lobe autopsy tissue from adult SCA8 (n = 3) and control fetal (n = 1) tissue. * = significant difference (p<0.01). (B) Protein blot showing up-regulation of GABT4 in SCA8 and fetal frontal lobe vs. DM1 and Control with GAPDH as loading control. (C) RT-PCR of GABT4 shows a shift favoring exon 7 inclusion transcripts in SCA8 and control fetal frontal lobe tissue vs. adult control and DM1.