Figure 8. Simulation results for proposed experimental protocols for (A) amplification of G-protein signaling in the presence of lipid rafts with 2% coverage, and (B) attenuation of G-protein signaling in the presence of lipid rafts with 30% coverage.

Baseline experiments are performed using k_hyd = 10 s⁻¹, R_tot = 50,000 #/cell and [L] = 0.1K_d. The effects of a change in a single parameter are shown by experiments I-III (experiment I∶k_hyd = 1 s⁻¹, experiment II∶R_tot = 250,000 #/cell and experiment III∶[L] = K_d). The effect of a simultaneous change in all three parameters is shown by experiment IV (k_hyd = 1 s⁻¹, R_tot = 250,000 #/cell and [L] = K_d). The greatest enrichment ratio for ligand-bound receptors predicted by MC model was used in each simulation. Other parameter values are as listed in Table 1.