Table 1. Model parameter values.
| MC model | |||
| Parameter | Definition | Value | Reference |
| kdimer (s−1)* | Receptor dimerization rate constant | 103–107 | [10], [34] |
| kmono (s−1) | Receptor monomerization rate constant | 103–107 | [10], [34] |
| kf (M−1s−1) | Ligand/receptor association rate constant | 108 | [26], [52] |
| kr (s−1) | Ligand/receptor dissociation rate constant | 1 | [52] |
| Draft (cm2/s) | Membrane diffusivity in the raft region | 10−12–10−11 | [14], [26], [36], [37] |
| Dnon-raft (cm2/s) | Membrane diffusivity in the non-raft region | 10−10–10−9 | [14], [26], [36], [37] |
| R (%) | Lipid raft coverage | 2–30 | [13], [14], [28], [30], [31] |
| d (nm) | Lipid raft diameter | 20–50 | [13], [14], [28], [30], [31] |
| ODE model | |||
| Parameter | Definition | Value † | Reference |
| kf (M−1s−1) | Ligand/receptor association rate constant | 107–108 (108) | [26], [52] |
| kr (s−1) | Ligand/receptor dissociation rate constant | 0.1–1 (1) | [52] |
| kf' (M−1s−1) | Ligand/phosphorylated receptor association rate constant | 106–109 (108) | [52] |
| kr' (s−1) | Ligand/phosphorylated receptor dissociation rate constant | 0.001–0.005 (0.002) | [52] |
| kon (M−1s−1) | Receptor/kinase association rate constant | 109–1011 (1011) | [52] |
| koff (s−1) | Receptor/kinase dissociation rate constant | 10–100 (25) | [52] |
| kint (s−1) | Receptor internalization rate constant | 10−4–10−1 (10−2) | [52], [74] |
| krec (M−1s−1) | G-protein recombination rate constant | 6×109–6×1011 (1.6×1010) | [52] |
| khyd (s−1) | GTP hydrolysis rate constant | 0.02–30 | [70], [75]–[77] |
| Rtot (#/cell) | Total number of cell surface receptors | 5×104–5×105 (2.5×105) | [52] |
| Gtot (#/cell) | Total number of G-proteins | 104–105 (7.5×104) | [52] |
| [L]/Kd | Scaled ligand concentration | 0.1–10 | |
| RKtot (M) | Total concentration of GPCR kinase | 1.5×10−9–3×10−9 (3×10−9) | [52] |
| r | Relative G-protein density | 0.02–0.8 | |
| Dnon-raft (cm2/s) | Membrane diffusivity in the non-raft region | 10−10–10−9 (10−10) | |
| kc, kc' (M−1s−1) | G-protein activation rate constant | Computed from Equation (1) | |
| Kclus | Clustering equilibrium constant | Found from MC simulation | |
| kp, kp' (M−1s−1) | Receptor phosphorylation rate constant | Computed similarly to kc and kc' | |
| Dnon-raft/Draft | Ratio of non-raft diffusivity to lipid raft diffusivity | 10 | |
*kdimer is an intrinsic rate constant, meaning that it describes the rate at which binding takes place after diffusion has brought the proteins within reaction range.