Table 2. Description of the reaction species, reactions and equations of the ODE model.

Reaction species
L	Ligand	Gclus	Trimeric G-protein in the raft region
R	G-protein coupled receptor	(βγ)clus	βγ-subunit of G-protein in the raft region
LR	Ligand/receptor complex	RK	GPCR kinase
LRscat	Ligand/receptor complex in the non-raft region	LR-P	Phosphorylated ligand-bound receptor
LRclus	Ligand/receptor complex in the raft region	R-P	Phosphorylated receptor
Gscat	Trimeric G-protein in the non-raft region	LRi	Internalized ligand-bound receptor
α-GTP	GTP-bound (active) α-subunit of G-protein	α-GDP	GDP-bound α-subunit of G-protein
(βγ)scat	βγ-subunit of G-protein in the non-raft region
ODE model reactions and flux expressions
1	L+R ↔ LR	7	[LRscat]∶Gscat → α−GTP+βγscat
2	βγscat+RK ↔ βγ−RKscat	8	[LRclus]∶Gclus → α−GTP+βγclus
3	βγclus+RK ↔ βγ−RKclus	9	α−GTP → α-GDP
4	[βγ−RKscat]∶LRscat → LR−Pscat	10	α−GDP+βγscat → Gscat
5	[βγ−RKclus]∶LRclus → LR−Pclus	11	α−GDP+βγclus → Gclus
6	L+R−P ↔ LR−P	12	LR−P → LRi
ODE model equations