Reaction species
|
L
|
Ligand |
Gclus
|
Trimeric G-protein in the raft region |
R
|
G-protein coupled receptor |
(βγ)clus
|
βγ-subunit of G-protein in the raft region |
LR
|
Ligand/receptor complex |
RK
|
GPCR kinase |
LRscat
|
Ligand/receptor complex in the non-raft region |
LR-P
|
Phosphorylated ligand-bound receptor |
LRclus
|
Ligand/receptor complex in the raft region |
R-P
|
Phosphorylated receptor |
Gscat
|
Trimeric G-protein in the non-raft region |
LRi
|
Internalized ligand-bound receptor |
α-GTP
|
GTP-bound (active) α-subunit of G-protein |
α-GDP
|
GDP-bound α-subunit of G-protein |
(βγ)scat
|
βγ-subunit of G-protein in the non-raft region |
|
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ODE model reactions and flux expressions
|
1 |
L+R ↔ LR |
7 |
[LRscat]∶Gscat → α−GTP+βγscat
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2 |
βγscat+RK ↔ βγ−RKscat
|
8 |
[LRclus]∶Gclus → α−GTP+βγclus
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3 |
βγclus+RK ↔ βγ−RKclus
|
9 |
α−GTP → α-GDP |
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4 |
[βγ−RKscat]∶LRscat → LR−Pscat
|
10 |
α−GDP+βγscat → Gscat
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5 |
[βγ−RKclus]∶LRclus → LR−Pclus
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11 |
α−GDP+βγclus → Gclus
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6 |
L+R−P ↔ LR−P |
12 |
LR−P → LRi
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ODE model equations
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