Table I.

Contribution of secreted and cytoplasmic control proteins from plant pathogenic bacteria to virulence

Bacterial Species/Predicted Protein Function	Proteina	Localizationb	Contribution to T3S and Virulence	Reference
E. amylovora:
Pilus protein	HrpA	S	Essential for disease and T3S	Jin et al. (2001)
Translocon proteins	HrpK	S	Homologous to HrpK1 from P. syringae, dispensable for virulence	Nissinen et al. (2007)
Control protein	HrpN	S+T	Harpin, contributes to translocation of the effector DspA/E	Bocsanczy et al. (2008)
	HrpJ	S	Required for virulence, contributes to secretion of harpins and translocation of the effector DspA/E	Nissinen et al. (2007); Bocsanczy et al. (2008)
P. syringae pv tomato:
Pilus protein	HrpA	S	Essential for disease and T3S	Roine et al. (1997)
Translocon protein	HrpK1	S+T	Contributes to disease and effector protein translocation	Petnicki-Ocwieja et al. (2005)
Control proteins	HrpZ1	S+T	Harpin, forms ion channels	Lee et al. (2001); Kvitko et al. (2007); Engelhardt et al. (2009)
	HrpW1	S+T	Harpin, C-terminal pectate lyase domain
	HopAK1	S+T	Harpin, C-terminal pectate lyase domain
			HrpZ1, HrpW, and HopAK1 contribute to effector protein translocation and disease
	HrpH	T	HrpH, HopP1, and HopAJ1 are predicted lytic transglycosylases and contribute to effector protein translocation and disease	Oh et al. (2007)
	HopP1	T
	HopAJ1	NT
	HrpJ	S+T	Required for disease, contributes to T3S	Fu et al. (2006)
	HrpP	T	Predicted T3S4 protein, essential for disease	Morello and Collmer (2009)
R. solanacearum:
Pilus protein	HrpY	S	Essential for disease and T3S	Van Gijsegem et al. (2000)
Translocon protein	PopF1	S	Essential for disease	Meyer et al. (2006)
	PopF2	S	Dispensable for disease	Meyer et al. (2006)
Control proteins	HpaB	n.a.	Required for disease	Mukaihara et al. (2004)
Xanthomonas spp.:
Pilus protein	HrpEXcv	S	Essential for disease and T3S	Weber et al. (2005)
Translocon protein	HrpFXcv	S	Essential for disease and effector protein translocation	Büttner et al. (2002)
	HrpFXoo	S	Contributes to disease	Sugio et al. (2005)
Control proteins	HpaAXcv	S+T	Contributes to disease, secreted regulator of HpaB	Lorenz et al. (2008a)
	HpaBXcv	C	Global T3S chaperone, essential for disease	Büttner et al. (2004)
	HpaCXcv	C	T3S4 protein, contributes to disease	Lorenz et al. (2008a)
	HpaHXcv	n.a.	Predicted lytic transglycosylase, contributes to effector protein translocation and disease	Büttner et al. (2007)

^aXcv, X. campestris pv vesicatoria; Xoo, X. oryzae pv oryzae.

^bLocalization: C, cytoplasmic; n.a., not analyzed; NT, not translocated; S, secreted; T, translocated.