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. 2000 Nov 7;97(24):13144–13149. doi: 10.1073/pnas.240336397

Figure 4.

Figure 4

Thyroglobulin promoter activity in PC, PCPy, and PCPy-Pax8 cells. (A) Schematic representation of the Tg reporter constructs, wild-type (Tg-CAT) and mutated in one of the TTF-1-binding site (Tg-CAT Acore). Gray ovals represent TTF-1, and the black rectangle represents Pax8. (B) PC, PCPy, and one PCPy-Pax8 clone (PCPy-4B2) were transiently transfected with 10 μg of wild-type Tg reporter construct (Tg-CAT) or of a mutated Tg reporter (Tg-CAT Acore), along with 2 μg of CMV-LUC. After normalization for LUC activity, the activity of the promoters was measured relative to that of a basal promoter.