Figure 6.

Decreasing TGF-β2 levels in Ltbp4S^−/− lungs does not rescue elastic fiber formation. Under conditions in which terminal air-sac septation was normalized (Fig. 5A and B), elastogenesis was still defective as indicated by the absence of elastic lamellae. Elastin in sections from P0.5 lungs was stained with orcinol - new fuchsin. The arrows point to the elastic fibers in WT and Tgfb2^−/− lungs and to the globular elastin in Ltbp4S^−/− and Ltbp4S^−/−;Tgfb2^−/− lungs. Bar: 10 µm.