Table 2. Loci from the WTCCC Study with Significant Associations with Coronary Artery Disease That Were Replicated in the German MI Family Study^*.

Chromosome	Lead SNP	Minor Allele in Controls	Risk Allele	Data	Frequency of Minor Allele		Odds Ratio for Risk Allele (95% CI)	Population Attributable Fraction	P Value
					Case Subjects	Controls
2	rs2943634	A	C	WTCCC	0.30	0.34	1.22 (1.11-1.33)		1.19×10−5
				German	0.32	0.37	1.20 (1.06-1.35)		0.004
				Adjusted German			1.08 (0.90-1.31)	0.10	0.03
6	rs6922269	A	A	WTCCC	0.29	0.25	1.23 (1.13-1.35)		6.33×10−6
				German	0.30	0.26	1.24 (1.09-1.41)		0.001
				Adjusted German			1.23 (1.01-1.50)	0.11	0.009
9	rs1333049	C	C	WTCCC	0.55	0.47	1.37 (1.26-1.48)		1.80×10−14
				German	0.54	0.48	1.33 (1.18-1.51)		6.80×10−6
				Adjusted German			1.28 (1.07-1.53)	0.22	6.12×10−5

^*For each SNP, the odds ratios (with 95% confidence intervals) and P values given for the WTCCC and German data represent the risk of coronary artery disease associated with each copy of the risk allele and are based on the Cochran–Armitage test for trend, without adjustment for covariates. The odds ratios and population attributable fractions for the adjusted German data are based on multivariate analyses with inclusion of all three lead SNPs and with adjustment for age, sex, the interaction between age and sex, the PROCAM study score, and the Framingham risk score. The P values for the adjusted German data were corrected for multiple testing (i.e., the testing of a total of nine loci for association with coronary artery disease) but were not adjusted for covariates. The location of the SNPs and details of their loci are shown in Figure 2 and in Figures 1A and 1B in the Supplementary Appendix. Further details on the SNPs, including genotype frequencies in the two studies, are given in Tables 1 and 3 in the Supplementary Appendix.