Table 1.
Association between the TCF7L2 (rs12255372) genetic variants with colorectal cancer and adenoma risk in the Nurses’ Health Study and Health Professionals Follow-up Study
| Cases N (%) |
Controls* N (%) |
Conditional OR1 (95% CI) |
Multivariate Conditional OR2 (95% CI) |
|
|---|---|---|---|---|
| NHS and HPFS CRC3 | ||||
| TCF7 L2 | N=357 | N=814 | ||
| GG | 199 (55.7) | 413 (50.7) | 1.00 (Reference) | 1.00 (Reference) |
| GT | 135 (37.8) | 328 (40.3) | 0.89 (0.68 – 1.16) | 0.90 (0.68 – 1.18) |
| TT | 23 (6.4) | 73 (9.0) | 0.64 (0.38 – 1.07) | 0.63 (0.37 – 1.08) |
| 4P-trend | 0.10 | |||
| GT+TT | 158 (44.3) | 401 (49.3) | 0.84 (0.69 – 1.03) | 0.84 (0.68 – 1.04) |
| NHS CRC | ||||
| TCF7L2 | ||||
| GG | 100 (53.2) | 233 (49.7) | 1.00 (Reference) | 1.00 (Reference) |
| GT | 81 (43.1) | 194 (41.4) | 0.99 (0.70 – 1.40) | 1.00 (0.68 – 1.46) |
| TT | 7 (3.7) | 42 (9.0) | 0.39 (0.17 – 0.91) | 0.39 (0.16 – 0.91) |
| P-trend | 0.14 | |||
| GT+TT | 88 (46.8) | 236 (50.4) | 0.81 (0.62 – 1.07) | 0.81 (0.60 – 1.07) |
| HPFS CRC | ||||
| TCF L2 | ||||
| GG | 101 (58.7) | 186 (52.8) | 1.00 (Reference) | 1.00 (Reference) |
| GT | 55 (32.0) | 135 (38.4) | 0.75 (0.50 – 1.13) | 0.78 (0.50 – 1.20) |
| TT | 16 (9.3) | 31 (8.8) | 0.96 (0.48 – 1.91) | 0.89 (0.42 – 1.89) |
| P-trend | 0.37 | |||
| GT+TT | 71 (41.3) | 166 (47.2) | 0.88 (0.66 – 1.17) | 0.87 (0.64 – 1.18) |
| NHS Adenoma | ||||
| TCF7L2 | ||||
| GG | 271 (51.8) | 273 (52.4) | 1.00 (Reference) | 1.00 (Reference) |
| GT | 218 (41.7) | 204 (39.2) | 1.06 (0.81 – 1.39) | 1.12 (0.83 – 1.51) |
| TT | 34 (6.4) | 44 (8.4) | 0.75 (0.45 – 1.24) | 0.74 (0.41 – 1.32) |
| P-trend | 0.83 | |||
| GT+TT | 252 (48.2) | 248 (47.6) | 0.95 (0.78 – 1.16) | 0.98 (0.78 – 1.22) |
HWE p-value for total NHS and HPFS controls is 0.50 (NHS cancer: HWE p=0.86 controls, p=0.05 cases; HPFS cancer: HWE p=0.36 controls, p=0.04 cases; NHS adenoma: HWE p=0.50 controls, HWE p=0.26)
Conditional logistic regression conditioned on the strata defined by the matching variables
Conditional logistic regression conditioned on the strata defined by the matching variables, and adjusted for family history of colon cancer, pack years smoked, body mass index, PMH use, BMI, aspirin intake, physical activity, alcohol intake, total folate consumption, and red meat consumption.
P for heterogeneity 0.52 for the association in women and men
Armitage test for trend