Table 2.
Association of TCF7L2 variants with covariates
| Cases N (%) |
Controls N (%) |
Multivariate OR1 (95% CI) |
P-int2 | ||
|---|---|---|---|---|---|
| TCF7L2 | Family History | ||||
| GG | No | 152 (42.9) | 335 (41.9) | 1.00 (Ref) | |
| GT+TT | No | 120 (33.9) | 334 (41.8) | 0.78 (0.58 – 1.06) | |
| GG | Yes | 45 (12.7) | 70 (8.8) | 1.35 (0.85 – 2.13) | |
| GT+TT | Yes | 37 (10.4) | 61 (7.6) | 1.39 (0.85 – 2.27) | |
| 0.45 | |||||
| TCF7L2 | BMI | ||||
| GG | <25 | 85 (24.0) | 185 (23.3) | 1.00 (Ref) | |
| GT+TT | <25 | 69 (19.5) | 190 (23.8) | 0.83 (0.55 – 1.24) | |
| GG | ≥25 | 112 (31.6) | 220 (27.5) | 1.02 (0.70 – 1.50) | |
| GT+TT | ≥25 | 88 (24.9) | 205 (25.6) | 0.84 (0.55 – 1.24) | 0.27 |
1
Logistic regression adjusted for family history of colon cancer, pack years smoked, body mass index (BMI), post-menopausal hormone (PMH) use, aspirin intake, physical activity, alcohol intake, total folate consumption, and red meat consumption.
2
P-int: p-values obtained from the likelihood ratio test (LRT) comparing models with and without the interaction term between genotype and covariate