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Intersection between HIF-1α- and HIF-2α-binding gene loci. A, gene loci that bound either HIF-1α or HIF-2α or both isoforms with a Z-score >4. B, defining HIF-1α capture with a Z-score of 3 encompasses almost all HIF-2α binding loci. C, defining HIF-2α capture with a Z-score of 3 excludes almost one-third of HIF-1α binding loci.
