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. 2009 May 1;284(25):16791–16798. doi: 10.1074/jbc.M808919200

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — KLF5 activates ERK-MKP-1 signaling through FGF-BP in breast cells. A, knockdown of either KLF5 or FGF-BP down-regulates pERK, pMKP-1^Ser-359, and total MKP-1 protein levels in MCF10A. B, FGF-BP depletion blocks KLF5 overexpression induced up-regulation of the pERK, pMKP-1^Ser-359, and total MKP-1 protein levels in MCF7. C, a linear model of KLF5 promoting breast cell survival. a, KLF5 directly induces the FGF-BP transcription. b, FGF-BP activates the ERK signaling. c, the activated ERK phosphorylates MKP-1 at Ser-359 and Ser-364 and prevents its degradation. d, the elevated MKP-1 promotes breast cell survival.