TABLE 1.
Body weight, liver weight, serum, and hepatic lipid profile of WT and Apobec-1−/− mice on both chow and lithogenic diets
Values represent the mean ± S.E. (n). ALT, alanine aminotransferase. mg/g, mg/g of liver.
| Parameters | Chow |
Lithogenic diet |
p | ||
|---|---|---|---|---|---|
| WT | Apobec-1−/− | WT | Apobec-1−/− | ||
| Body weight (g) | 26.53 ± 0.77 (12) | 26.88 ± 0.88 (13) | 23.64 ± 0.40 (17) | 23.59 ± 0.46 (22) | |
| Liver wt (g) | 1.27 ± 0.04 (12) | 1.19 ± 0.03 (13) | 1.53 ± 0.05 (18) | 1.08 ± 0.03 (22) | p < 0.01a |
| Liver wt (% body wt) | 4.81 ± 0.19 (12) | 4.46 ± 0.11 (13) | 6.76 ± 0.18 (18) | 5.03 ± 0.13 (22) | p < 0.01a |
| Serum cholesterol (mg/dl) | 62.17 ± 2.79 (12) | 65.33 ± 3.04 (13) | 146.37 ± 5.17 (8) | 156.36 ± 7.91 (10) | |
| Serum triglyceride (mg/dl) | 28.43 ± 3.26 (20) | 57.05 ± 5.13 (22) | 24.43 ± 2.74 (12) | 52.84 ± 11.74 (14) | p < 0.05a; p < 0.05b |
| Serum bile acid (μmol/liter) | 6.11 ± 1.21 (4) | 6.88 ± 1.10 (5) | 16.56 ± 3.28 (8) | 22.41 ± 4.46 (10) | |
| Serum ALT (IU/liter) | 10.45 ± 3.97 (7) | 15.86 ± 2.59 (8) | 59.87 ± 11.04 (8) | 49.35 ± 10.30 (14) | |
| Hepatic cholesterol (mg/g) | 1.21 ± 0.06 (5) | 1.31 ± 0.09 (5) | 19.11 ± 0.91 (12) | 15.61 ± 0.64 (15) | p < 0.01a |
| Hepatic triglyceride (mg/g) | 3.71 ± 0.42 (5) | 4.86 ± 0.81 (5) | 15.67 ± 1.28 (12) | 12.73 ± 0.73 (15) | p < 0.05a |
| Hepatic phospholipid (mg/g) | 5.29 ± 0.22 (5) | 5.77 ± 0.31 (5) | 15.24 ± 0.55 (12) | 14.80 ± 0.56 (15) | |
| Hepatic free fatty acid (μmol/g) | 1.05 ± 0.14 (5) | 1.45 ± 0.18 (5) | 3.76 ± 1.15 (12) | 2.91 ± 0.14 (15) | |
a Comparing WT and Apobec-1−/− mice on lithogenic diet.
b Comparing WT and Apobec-1−/− mice on chow diet.