TABLE 2.

Liver microarray data for chow

Gene name	Gene description	Accession number	Ratioa	qRT-PCR	p
Bile acid synthesis, transport, and metablolism
Cyp7a1	Cholesterol 7α-hydroxylase	NM_007824	0.17	0.25b	0.01
Cyp8b1	Sterol 12α-hydroxylase	NM_010012	0.31	1.15b
Cyp27a1	Sterol 27-hydroxylase	NM_024264	0.65	0.9
Bsep/Abcb11	Bile salt export pump	NM_021022	0.9	0.75
Ntcp	Na+-taurocholate co-transporting protein	NM_011387	0.98	1.42
Oatp4	Organic anion transporter, 1b2	NM_178235	1.07	1.28
Oatp2	Organic anion transporter, 1a4	NM_030687	1.5	1.69
Mdr2/Abcb4	ATP-binding cassette, B4	NM_008830	1.25
Mrp2/Abcc2	ATP-binding cassette, C2	NM_013806	1.1
Cyp2b10	Cytochrome P450, 2b10	NM_009998	0.73	2.97
Cyp3a11	Cytochrome P450, 3a11	NM_007818	0.7	0.51
Cholesterol synthesis and transport
Hmgcr	Hydroxymethylglutaryl-CoA reductase	NM_008255	0.7	1.64b
Abca1	ATP-binding cassette, A1	NM_013454	1.4	1
Abcg5	ATP-binding cassette, G5	NM_031884	1	1.3
Abcg8	ATP-binding cassette, G8	NM_026180	1	1.5
Srb1	Scavenger receptor class, B1	NM_016741	1.1	1.28
Scp2	Sterol carrier protein 2, liver	NM_011327	1.3	0.66
Lfabp	Liver fatty acid-binding protein	NM_017399	1.2	1.06
Cav1	Caveolin 1	NM_007616	1.0	1.12
Npc1	Niemann-Pick type C1	NM_008720	0.9
Transcription factors or nuclear receptors
Lxrα	Liver X receptor α	NM_013839	0.81	0.94b
Fxr	Farnesoid X receptor	NM_009108	1.3	1.16
Shp	Small heterodimer partner	NM_011850	0.66	0.37
Pparα	Peroxisome proliferator-activated receptor α	NM_011144	1.5	1.6
Srebp1	Sterol regulatory element-binding protein 1	NM_011480	0.8	0.6b
Srebp2	Sterol regulatory element-binding protein 2	NM_033218	0.99	1.1
Pxr	Pregnane X receptor	NM_010936	1.2	1.33
Lrh-1	Liver receptor homolog	NM_030676	0.98
Fatty acids synthesis and oxidation
Fasn	Fatty acid synthase	NM_007988	1.1	0.4
Ucp2	Uncoupling protein 2	NM_011671	1.1	1.03
Scd1	Stearoyl-coenzyme A desaturase 1	NM_009127	0.9	0.43
Scd2	Stearoyl-coenzyme A desaturase 2	NM_009128	1.1	0.58
Acc	Acetyl-coenzyme A carboxylase α	NM_133360	0.9
Lipoprotein metabolism
ApoB	Apolipoprotein B	XM_137955	2.06	1.08b
ApoA4	Apolipoprotein A-IV	NM_007468	0.53	0.95
ApoC3	Apolipoprotein C-III	NM_023114	1.2	0.7
ApoC2	Apolipoprotein C-II	NM_009695	1	0.92
Ldlr	Low density lipoprotein receptor	NM_010700	0.65	0.89
ApoA1	Apolipoprotein A	NM_009692	0.94
ApoE	Apolipoprotein E	NM_009696	1.2
Others
Cyp2C38	Cytochrome P450, 2C38	NM_010002	0.8	0.7
Cyp4a14	Cytochrome P450, 4A14	NM_007822	1.6	0.4

^a Microarray data are expressed as a ratio of Apobec1^−/− versus WT. Relative mRNA expression of some genes was confirmed by real time qRT-PCR by using pooled cDNA (5 mice/group). qRT-PCR results are expressed as -fold change normalized to WT control.

^b Relative mRNA expression of the indicated genes was confirmed using individual samples (n = 4).