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. 2009 Apr 14;284(25):17304–17319. doi: 10.1074/jbc.M109.003194

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — SAR for 1-acyl-LPA analogs at LPA₅ and model of the receptor-ligand complexes. A, intracellular Ca²⁺ transients were measured in response to different 1-acyl-LPA species in RH7777 cells transiently expressing LPA₅. 100% represents the maximal response to LPA 18:1. Samples were run in triplicate, and the mean ± S.D. was plotted. B, comparison of docked phosphate headgroups for LPA18:1 (light green), 18:2 (dark green), 18:3 (light yellow), 20:4 (dark yellow), 16:0 (orange), 18:0 (red), and 20:0 (purple).