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. 2009 May 1;284(26):17668–17676. doi: 10.1074/jbc.M109.002931

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Origin and effect of AMP accumulation during PARP-1 activation. A, time-dependent AMP accumulation in cells exposed to MNNG and effect of pharmacological inhibition of PARP-1 (phenanthridinone (PHE) 30 μm and N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide (PJ34) 10 μm), PARG (GPI-16552, 100 μm), or PARG siRNA. B and C, effect of LY294002, chelerythrine, cumaric acid, and flavone on cellular NUDIX activity (B) and MNNG-induced ATP depletion (C). D, the capacity of a set of compounds to prevent MNNG-induced ATP depletion correlates with their ability to inhibit NUDIX activity or prevent AMP increase. Bars/points represent the mean ± S.E. of at least three experiments conducted in duplicate.