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. 2009 May 1;284(26):17668–17676. doi: 10.1074/jbc.M109.002931

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — AMP impairs ANT functioning by competing with the ADP binding site. A, effect of AMP on ADP-dependent ATP production by isolated mitochondria. B, effect of increasing ADP concentrations on AMP-dependent inhibition of mitochondrial ATP production. CRL, control. C, effect of ATR (100 μm) or AMP on binding of [¹⁴C]ADP to mitochondria (inset, saturation curve). D, effect of AMP on mitochondrial ADP uptake and ATP output; inset, the effect of AMP is not additive to that of ATR. Bars/points represent the mean ± S.E. of at least three experiments conducted in duplicate.