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. 2009 May 1;284(26):17668–17676. doi: 10.1074/jbc.M109.002931

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Effect of ADP and AMP on ATP production by in situ mitochondria. A, effect of externally added ADP or AMP (both at 100 μm) or ATR (10 μm) on light emission by permeabilized mit-luciferase-transfected cells previously exposed to MNNG. MNNG was added at time 0, compounds were added together with permeabilization at time 15 min, luciferin was added at time 45 min, and light emission was recorded at time 50 min. CRL, control. B, effect of ADP and AMP concomitantly added at concentrations found in cells under control conditions (ADP+AMP_CTRL) or challenged for 30 min with MNNG (ADP+AMP_MNNG). MNNG was added at time 0, compounds were added together with permeabilization at time 30 min, luciferin was added at time 35 min, and light emission was recorded 2.5, 5, and 10 min after luciferin addition. Bars/points represent the mean ± S.E. of at least three experiments conducted in duplicate. In B, an experiment representative of three is shown.