FIGURE 7.

Schematic of SenP5 transition and the DRP1 SUMOylation cycle. A, illustrates the translocation of SenP5 from the nucleoli to the mitochondria at G₂/M, which coincides with the global deSUMOylation of mitochondrial targets and increase in mitochondrial fission. B, our data indicates that the SUMOylation cycle of DRP1 is enhanced upon delivery of SenP5 to the membrane. The deSUMOylation of DRP1 helps to drive the oligomerization of DRP1, which promotes mitochondrial fission during mitosis.