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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Nov 14;50(3):1129–1136. doi: 10.1167/iovs.08-2525

Figure 7. Schematic representation of the role TGFBIp and CLU in guttae formation.

Figure 7

There is a gradually increasing production of TGFBIp and CLU in the centers of guttae. TGFBIp accumulates in close proximity to the Descemet’s membrane, while CLU forms aggregates on top of the TGFBIp deposits at the endothelial cell level. Both TGFBIp and CLU co-localize in the middle of the guttae (circular insert).