Table 4.

p53 mutations and BRCA1 protein level in primary sporadic ovarian carcinomas

	P53 Mutations
BRCA1 protein Expression	Total Tested	Missense N (%)	Null N (%)	Total P53 mutations
Low	28	10 (36%)	5 (18%)	15 (54%)
Intermediate	18	8 (44%)	2 (11%)	10 (56%)
Normal	33	6(18%)	2 (6%)	8 (24%)*
Total	79	24 (30%)	9 (11%)	33 (42%)

*p = 0.01 for difference in p53 mutation frequency for cases with normal versus reduction or loss of BRCA1 protein.