Table 4.

Parameters of the complete cAMP pathway Model

Parameter name	Value	Units	Source
Glucose transport KM	0.08	mM	[37]
Glucose transport V	1.7	mmol/s	[37]
Glucose transport Ki	0.91		[37]
Glucose Utilisation kF	0.03	l/s	This work
Gpr1 Glucose association k1	0.003	l2/mmol*s	This work
Gpr1 Glucose dissociation k1	0.14	l/s	This work
Gpa2 activation kA	57682.6	l2/mmol*s	This work
Gpa2 deactivation kF	0.899	l/s	This work
Gpa2 deactivation kA	12989.4	l2/mmol*s	This work
Gpa2-Krh association kF	391089.6	l2/mmol*s	This work
Gpa2-Krh dissociation kF	6.12	l/s	This work
Ras2 activation kcat	0.74	l/s	This work
Ras2 activation KM	1.38 × 10-3	mmol/l	This work
Ras2 activation Kd	0.044	mmol/l	This work
Ras2 activation a	32.9		This work
Ras2 activation b	63.8		This work
Ras2 deactivation kF	0.042	l/s	This work
Ras2 deactivation kA	519.8	l2/mmol*s	This work
cAMP synthesis kcatGpa2	2933.9		This work
cAMP synthesis kcatRas2	650		This work
cAMP synthesis KM	4 × 10-3	mM	This work
PKA activation kF	7.6 × 108		This work
PKA activation kI	100	l/mmol	This work
PKA deactivation kF	19.9		This work
PKA deactivation kA	2.2 × 104	l/mmol	This work
Cdc25 phosphorylation kcat	0.18	l/s	This work
Cdc25 phosphorylation KM	5.2 × 10-3	mmol/l	This work
Cdc25 dephosphorylation kcat	2.52	l/s	This work
Cdc25 dephosphorylation KM	1.6 × 10-2	mmol/l	This work
Pde1 phosphorylation kcat	6.82	l/s	This work
Pde1 phosphorylation KM	8.6 × 10-3	mmol/l	This work
Pde1 dephosphorylation kcat	2.4	l/s	This work
Pde1 dephosphorylation KM	1.07 × 10-3	mmol/l	This work
cAMP hydrolysis (Pde1) kcat	1.1	l/s	This work
cAMP hydrolysis (Pde1) KM	0.85	mmol/l	This work
cAMP hydrolysis (Pde1p) kcat	25.25	l/s	This work
cAMP hydrolysis (Pde1p)KM	6 × 10-7	mmol/l	This work
cAMP hydrolysis (Pde2)kcat	1	l/s	This work
cAMP hydrolysis (Pde2) KM	0.002	mmol/l	[15]