Skip to main content
. 2009 Jul 16;3:70. doi: 10.1186/1752-0509-3-70

Table 5.

Reactions of the Complete cAMP pathway Model

Reaction name Substrates Products Rate law
Glucose transport (reversible) Glucout Glucin Inline graphic

Glucose metabolism Glucin kf [Glucin]

Gpr1-Glucose Association Gpr1, Glucout Gpr1Glucout kf [Gpr1] [Glucout]

Gpr1-Glucose dissociation Gpr1Glucout Gpr1,Glucout kf [Gpr1Glucout]

Gpa2 activation Gpa2i Gpa2a kA [Glucout] [Gpa2i]

Gpa2 deactivation Gpa2a Gpa2i (kA [Rgs2] + kf) [Gpa2a]

Gpa2-Krh association Gpa2a,Krh Gpa2aKrh kf [Gpa2a] [Krh]

Gpa2-Krh dissociation Gpa2aKrh Gpa2a,Krh kf [Gpa2aKrh]

Ras2 activation Ras2i Ras2a Inline graphic

Ras2 deactivation Ras2a Ras2i (kA[Ira]+kf)·[Ras2a]

cAMP synthesis cAMP Inline graphic

PKA activation PKAi 2*C Inline graphic

PKA deactivation 2*C PKAi kf[C]2·(1 + (kA[Krh]))

Cdc25 phosphorylation Cdc25 Cdc25P Inline graphic

Cdc25 dephosphorylation Cdc25P Cdc25 Inline graphic

Pde1 phosphorylation Pde1 Pde1P Inline graphic

Pde1 dephosphorylation Pde1P Pde1 Inline graphic

cAMP hydrolysis (Pde1) cAMP Inline graphic

cAMP hydrolysis (Pde1P) cAMP Inline graphic

cAMP hydrolysis (Pde2) cAMP Inline graphic