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Average collagen released from explants after 28 days of culture. Explants were cultured in serum free media containing IL-1β (100 ng/ml) and OSM (50 ng/ml) along with tepoxalin (T) or its metabolite (M) at ×10-5, ×10-6 or ×10-7 M concentrations. Values represent means + standard error, n = 7. P values correspond to comparisons to the positive control; * significant at p ≤ 0.05.
