Table 2.
Selected up-regulated genes identified in HNSCC*
| GeneBank Access ID | Gene Symbol & Annotation | Log2 Fold Difference** |
| Immune Response | ||
| L19686 | MIF, macrophage migration inhibitory factor | 3.1 |
| M13560 | CD74, CD74 antigen | 2.6 |
| M63438 | IGKC, immunoglobulin kappa constant | 1.9 |
| J03909 | IFI30, interferon, gamma-inducible protein 30 | 1.5 |
| AJ251549 | IL26, interleukin 26 | 1.4 |
| L33930 | CD24, CD24 antigen | 1.4 |
| X16302 | IGFBP2, insulin-like growth factor binding protein 2 | 1.4 |
| S75725 | IGFBP7, insulin-like growth factor binding protein 7 | 1.4 |
| Cell Growth, Maintenance/Cell cycle Regulation | ||
| Y00503 | KRT19, keratin 19 | 3.9 |
| U43901 | LAMR1, laminin receptor 1 | 3.2 |
| AL031670 | FTL, ferritin, light polypeptide | 2.5 |
| J00124 | KRT14, keratin 14 | 2.5 |
| X07696 | KRT 15, keratin 15 | 2.4 |
| X95404 | CFL1, cofilin 1 | 2.3 |
| D13627 | CCT8, chaperonin subunit 8 | 2.1 |
| AF026291 | CCT4, chaperonin subunit 4 | 2.0 |
| Z68228 | JUP, junction plakoglobin | 1.9 |
| M26326 | KRT18, keratin 18 | 1.8 |
| L42583 | KRT6C, keratin 6C | 1.7 |
| Translation and Protein Synthesis | ||
| AK001313 | RPLP0, ribosomal protein LP0 | 4.1 |
| L06499 | RPL37A, ribosomal protein L37A | 3.9 |
| U73824 | EIF4G2, translation initiation factor 4 gamma 2 | 3.2 |
| M64241 | RPL10, ribosomal protein L10 | 3.2 |
| X69150 | RPS18, ribosomal protein S18 | 3.1 |
| M84711 | RPS 3A, ribosomal protein S3A | 3.0 |
| NM_000996 | RPL35A, ribosomal protein L35A | 3.0 |
| U25789 | RPL21, ribosomal protein L21 | 2.9 |
| L11566 | RPL18, ribosomal protein L18 | 2.8 |
| Z21507 | EEF1D, eukaryotic translation elongation factor 1D | 2.3 |
| AL117412 | EIF4A2, eukaryotic translation initiation factor 4A | 2.2 |
| AC002544 | EIF3S8, eukaryotic translation initiation factor 3, subunit 8 | 2.1 |
| Metabolism | ||
| Z23090 | HSPB1, heat shock 27 kDa protein | 4.2 |
| M94856 | FABP5, fat acid binding protein 5 | 3.7 |
| NM_021130 | PPIA, peptidylprolyl isomerase A (cyclophilin A) | 2.9 |
| M26252 | PKM2, pyruvate kinase, muscle | 2.6 |
| NM_001679 | ATP1B3, ATP synthase Na+/K+ transporting, beta 3 | 2.6 |
| AF061735 | ATP5H, ATP synthase H+ transporting subunit | 2.1 |
| Y00483 | GPX1, glutathione peroxidase 1 | 2.0 |
| AL021546 | COX6A1, cytochrome c oxidase subunit VI a1 | 1.9 |
| X13923 | COX6B, cytochrome c oxidase subunit VI b | 1.8 |
| X13794 | LDHB, lactate dehydrogenase B | 1.7 |
| Z85996 | CDKN1A, cyclin-dependent kinase inhibitor 1A | 1.7 |
| M60483 | PPP2CA, protein phosphatase 2 catalytic subunit | 1.7 |
| Y13936 | PPM1G, protein phosphatase 1G | 1.6 |
| U09813 | ATP5G3, ATP synthase H+ transporting subunit | 1.6 |
| D29011 | PSMB5, proteasome subunit, beta 5 | 1.6 |
| AF047181 | NDUFB5, NADH dehydrogenase beta subcomplex 5 | 1.5 |
| Ion Binding Proteins | ||
| Y07755 | S100A2, S100 calcium binding protein A2 | 3.6 |
| D38583 | S100A11, S100 calcium binding protein A11 | 2.4 |
| NM_020672 | S100A14, S100 calcium binding protein A14 | 1.9 |
| X99920 | S100A13, S100 calcium binding protein A13 | 1.2 |
| Others | ||
| M14328 | ENO1, enolase 1 | 3.3 |
| M26880 | UBC, ubiquitin C | 3.2 |
| S54005 | TMSB10, thymosin, beta 10 | 2.8 |
| D87953 | NDRG1, M-myc downstream regulated gene 1 | 2.4 |
| M36981 | NME2, non-metastatic cells 2 protein | 2.3 |
| AF055008 | GRN, granulin | 2.3 |
| X57348 | SFN, stratifin | 2.3 |
| U46751 | SQSTM1, sequestosome 1 | 2.2 |
| X67951 | PRDX1, peroxiredoxin 1 | 2.1 |
| X65607 | MT1X, metallothionein 1X | 1.5 |
| X84709 | FADD, Fas associated death domain | 1.2 |
* All selected genes with p-value < 0.01.
**Log2 ratio fold-differences between tumors and normal tissues were determined by subtracting the ratio of genes in normal tissue versus uRNA from the ratio of genes in HNSCC tissues versus uRNA. (Log2 ratio of 1 equals to 2-fold difference between HNSCC and normal tissue; Log2 ratio of 2 equals to 4-fold difference between HNSCC and normal tissue, and so on)