Fig. 1.

(A) Superposition of hTP molecule in the native (gray) and in complex with 5IUR (light orange). Highlighted in green are the three loops (L1–L3) and in magenta is the hinge region. (B) Crystal packing of hTP–5IUR complex. The figures were created using Pymol (www.pymol.org). (C) Stereo view of the active site with bound 5IUR in the hTP–5IUR complex. Potential hydrogen bonds are illustrated with dotted lines. The electron density map (2F_o − F_c) around 5IUR is contoured at 1.0σ level. The figure was created using Molscript [24].