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Bias of BPND for different compartment models for simulated [18F]FDDNP data (obtained using 2T4k) as function of variable target influx rates (K1 target). Error bars represent SD in bias. K1 in reference region was fixed to 0.35, and K1/k2 was fixed to 3.3 for both target and reference regions. 2T4ki and SRTM represent indirect (using volumes of distribution) two-tissue reversible and simplified reference tissue models, respectively.
