Table 1.

Kinetic parameters used to generate reference (R) and target (T) tissue time activity curves (TAC)

TAC	K1 (ml·cm−3·min−1)		Vb	VT
R 1	0.35	1.63	0.050	8.7	–
T 1	0.35	2.3	0.050	11	0.25
T 2	0.35	1.7	0.050	8.9	0.03
T 3	0.35	2.0	0.050	9.9	0.14
T 4	0.35	2.6	0.050	12	0.37
T 5	0.35	2.9	0.050	13	0.48
T 6	0.35	2.3	0.025	11	0.25
T 7	0.35	2.3	0.075	11	0.25
T 8	0.21	2.3	0.050	11	0.25
T 9	0.25	2.3	0.050	11	0.25
T 10	0.28	2.3	0.050	11	0.25
T 11	0.32	2.3	0.050	11	0.25
T 12	0.39	2.3	0.050	11	0.25
T 13	0.43	2.3	0.050	11	0.25
T 14	0.46	2.3	0.050	11	0.25
T 15	0.50	2.3	0.050	11	0.25

K₁, k₂, and k₃ are rate constants, V_b is fractional blood volume, V_T is volume of distribution, and and are binding potentials estimated directly (2T4k) and indirectly (2T4kⁱ) using the reversible two-tissue model, respectively. The indirect calculation of BP_ND was performed using target to reference volumes of distribution ratios. During all simulations, k₄ (0.032 min⁻¹) and K₁/k₂ (3.3) were fixed