Table 2.

Kinetic parameters used to generate reference (R) and target (T) TAC

TAC	K1 (ml·cm−3·min−1)		Vb	VT		K1m (ml·cm−3·min−1)	VTm
R 1	0.34	0.65	0.05	4	–	–	–
T 1	0.34	1.3	0.05	5.59	0.39	0.50	0.59
T 2	0.34	0.8	0.05	4.37	0.09	0.50	0.6
T 3	0.34	1.0	0.05	4.86	0.21	0.50	0.6
T 4	0.34	1.2	0.05	5.34	0.33	0.50	0.6
T 5	0.34	1.4	0.05	5.83	0.45	0.50	0.6
T 6	0.34	1.6	0.05	6.31	0.58	0.50	0.6
T 7	0.34	1.8	0.05	6.80	0.70	0.50	0.6
T 8	0.34	2.1	0.05	7.53	0.88	0.50	0.6
T 9	0.34	2.3	0.05	8.01	1.00	0.50	0.6
T 10	0.34	1.3	0.05	5.59	0.39	0.00	0.6
T 11	0.34	1.3	0.05	5.59	0.39	0.01	0.6
T 12	0.34	1.3	0.05	5.59	0.39	0.03	0.6
T 13	0.34	1.3	0.05	5.59	0.39	0.05	0.6
T 14	0.34	1.3	0.05	5.59	0.39	0.50	0.1
T 15	0.34	1.3	0.05	5.59	0.39	0.50	0.2
T 16	0.34	1.3	0.05	5.59	0.39	0.50	0.3
T 17	0.34	1.3	0.05	5.59	0.39	0.50	0.4
T 18	0.34	1.3	0.05	5.59	0.39	0.50	0.5
T 19	0.34	1.3	0.05	5.59	0.39	0.50	0.7
T 20	0.34	1.3	0.05	5.59	0.39	0.50	0.8
T 21	0.34	1.3	0.05	5.59	0.39	0.50	0.9

A two-tissue reversible compartmental model with an additional single-tissue compartment for metabolites was used. K₁, k₂, and k₃ are rate constants, V_b is fractional blood volume, and V_T is volume of distribution for [¹⁸F]FDDNP. and and are binding potentials estimated directly and indirectly using the metabolite model, respectively. The indirect calculation of BP_ND was performed using target to reference volumes of distribution ratios. K_1m is a rate constant and V_Tm the volume of distribution for the metabolites. During all simulations, k₄ (0.099 min⁻¹) and K₁/k₂ (2.4) were fixed, and same, the K_1m and k_2m were used in reference and target tissues