Table 4.

Average (±SD) values of the kinetic parameters together with their range given between brackets for the 2T1M metabolite model

Data	K1	k2	k3		VT		Vb	K1m	VTm
HC ctx	0.28 ± 0.05 (0.2–0.4)	0.33 ± 0.30 (0.09–0.68)	1.06 ± 0.75 (0.01–2.43)	3.07 ± 2.89 (0.4–11)	3.70 ± 0.62 (3–5)	0.03 ± 0.14 (−0.18–0.44)	0.03 ± 0.01 (0.01–0.05)	0.08 ± 0.10 (0.01–0.5)	0.66 ± 0.07 (0.49–0.76)
AD ctx	0.41 ± 0.10 (0.3–0.6)	0.24 ± 0.15 (0.09–0.73)	0.54 ± 0.50 (0.05–1.84)	2.06 ± 1.65 (0.6–8)	5.19 ± 0.86 (4–7)	0.06 ± 0.11 (−0.2–0.3)	0.04 ± 0.02 (0.01–0.09)	0.16 ± 0.27 (0.03–0.93)	0.65 ± 0.06 (0.55–0.78)
AD + HC cer	0.39 ± 0.13 (0.3–0.6)	0.28 ± 0.16 (0.10–0.53)	0.49 ± 0.47 (0.04–1.30)	1.89 ± 1.42 (0.5–4)	4.24 ± 1.07 (3–6)	–	0.02 ± 0.02 (0.01–0.05)	0.34 ± 0.46 (0.02–1.00)	0.60 ± 0.04 (0.53–0.67)

These consisted of several typical AD cortical (ctx, i.e., orbital frontal cortex, medial inferior frontal cortex, anterior cingulate cortex, superior temporal cortex, parietal cortex, medial inferior temporal cortex, superior frontal cortex, enthorinal cortex, hippocampus) and cerebellar (cer) gray matter regions from healthy controls (HC) and AD subjects. K₁ and K_1m are given in ml·cm⁻³·min⁻¹, k₂ and k₃ in min⁻¹. and are binding potentials estimated directly and indirectly, respectively, using the reversible two-tissue plasma input model. and are binding potentials estimated directly and indirectly, respectively, using the metabolite model. is the binding potential estimated using the simplified reference tissue model