Table 7.
Average bias and absolute difference (diff.) with simulated BPND over a range of simulated 
for various reference tissue models
| Model | Bias (%) | SD in bias (%) | Diff. | SD in diff. |
|---|---|---|---|---|
| 2T4ki | 1 | 17 | 0.041 | 0.033 |
| SRTM | −12 | 16 | 0.053 | 0.062 |
| FRTM | −13 | 23 | 0.094 | 0.175 |
| SUVr40–60 | −1 | 14 | 0.034 | 0.026 |
| SUVr60–90 | 16 | 15 | 0.054 | 0.037 |
| SUVr80–90 | 22 | 33 | 0.095 | 0.072 |
In addition, corresponding SD are given. In the case of SUVr methods, SUVr − 1 was taken as an estimate of BPND. For bias, the range was set from 0.25 to 0.48 due to the large relative biases at lower specific binding. For absolute difference, the range was set from 0.03 to 0.48